Therotropin-Releasing Hormone (TRH)

The simplest of thyrotropin-releasing hormones, hypothalamic neurohormones, is the three amino acids in the glutamic acid–histidine–proline sequence. The therapeutic simplicity of thyrotropin-releasing hormones is cheating because this hormone actually has many functions. This stimulates the synthesis and secretion of thyrotropin (thyroid-stimulating hormone) by the anterior pituitary gland. Given the high dose by injection, it stimulates the secretion of prolactin from the pituitary gland, although it does not seem to control the secretion of prolactin. Therotropin-releasing hormone is also found in the entire brain and spinal cord, where it is thought to act as a neuromodulator.

Thyrotropin-releasing hormone appeared very quickly in the development of vertebrae, and, while its concentration is the highest in the hypothalamus, the total amount of thyrotropin-releasing hormones in the rest of the brain is much higher in the hypothalamus. The neurotransmitters producing thyrotropin-releasing hormones in the hypothalamus are subject to stimulant and inhibitory effects from the upper centers of the brain and serum thyroid hormone concentrations, stimulating low concentrations and high concentrations inhibit the production of thyrotropin-releasing hormones. Read More

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